Marjolin's Ulcer, A Frequent and Preventable Complication

Main Article Content

Hiebda Sofía Martinez Jiménez
Paola Daniela Guerrero Ramírez
María Fernanda Guijosa Ortega
Karla Itzel Sánchez Gutiérrez
Norma Melissa Salazar Ramirez

Abstract

Marjolin's ulcer is a malignant neoplasm originating from long-standing or previously healed skin lesions. Well-differentiated squamous cell carcinoma (SCC) is the most common histologic type. It is an aggressive neoplasm with a poor prognosis and high recurrence rates. It predominates in men and has a higher incidence in the fifth decade of life. The diagnosis is histopathological. Surgical excision is the treatment of choice. Early diagnosis and prevention in wound management reduce complications and guide the correct therapeutic approach.

Article Details

How to Cite
Hiebda Sofía Martinez Jiménez, Paola Daniela Guerrero Ramírez, María Fernanda Guijosa Ortega, Karla Itzel Sánchez Gutiérrez, & Norma Melissa Salazar Ramirez. (2023). Marjolin’s Ulcer, A Frequent and Preventable Complication. International Journal of Medical Science and Clinical Research Studies, 3(3), 403–406. https://doi.org/10.47191/ijmscrs/v3-i3-23
Section
Articles

References

I. Khan K, Schafer C, Wood J. Marjolin Ulcer: A Comprehensive Review. Advances in Skin & Wound Care. 2020 Dec;33(12):629–34

II. González-Vargas I, Tamez-Pedroza L, Facio-Treviño JÁ, Pacheco-Molina C, Treviño-García LA, Treviño-Lozano MA, et al. Úlcera de Marjolin y carcinoma espinocelular en paciente con antecedente de quemaduras. Cirugía Plástica. 2021;31(2):72–6.

III. Bazaliński D, Przybek-Mita J, Barańska B, Więch P. Marjolin's ulcer in chronic wounds - review of available literature. Contemp Oncol (Pozn). 2017;21(3):197-202. doi: 10.5114/wo.2017.70109.

IV. Conlon C, Pupa L, Reece EM, Chu CK, Yu JZ, Vorstenbosch J, Winocour S. When Benign Becomes Cancer: Malignant Degeneration of Chronic Inflammation. Semin Plast Surg. 2021 Aug;35(3):159-163. doi: 10.1055/s-0041-1731462

V. Barr LH, Menard JW: Marjolin’s Ulcer, the LSU experience. Cancer, USA 52: 173-175, 1983

VI. .Kowal-Vern A, Criswell BK. Burn scar neoplasms: a literature review and statistical analysis. Burns. 2005 Jun;31(4):403-13. doi: 10.1016/j.burns.2005.02.015.

VII. Chang, J. B., Kung, T. A., & Cederna, P. S. (2014). Acute Marjolin’s ulcers: a nebulous diagnosis. Annals of Plastic Surgery, 72(5), 515–520. doi:10.1097/SAP.0000000000000134

VIII. Iqbal, F. M., Sinha, Y., & Jaffe, W. (2015). Marjolin’s ulcer: a rare entity with a call for early diagnosis. BMJ Case Reports, 2015, bcr2014208176. doi:10.1136/bcr-2014-208176

IX. Khan, K., Schafer, C., & Wood, J. (2020). Marjolin ulcer: A comprehensive review. Advances in Skin & Wound Care, 33(12), 629–634. doi:10.1097/01.ASW.0000720252.15291.18

X. Wooldridge, A. N., Griesser, M. J., Scharschmidt, T., & Iwenofu, O. H. (2011). Development of Marjolin’s ulcer within one month of burn injury with synchronous primary lung squamous cell carcinoma in an elderly patient: report of a case with allelotyping. Medical Oncology (Northwood, London, England), 28 Suppl 1(S1), S586-92. doi:10.1007/s12032-010-9744-4

XI. Chen, B., Yue, X., Zha, W., Xu, M., Gao, Q., Wang, F., … Wu, J. (2020). Analysis of factors affecting chronic ulcers of scalp transforming into Marjolin’s ulcer: A single center experience. Journal of Burn Care & Research: Official Publication of the American Burn Association, 41(6), 1279–1289. doi:10.1093/jbcr/iraa094

XII. Ko, Y., Han, Y. M., Hwang, H. S., Kang, I. W., Hwang, D. H., Lee, E. S., & Lee, G. K. (2012). Role of 18F-FDG PET/CT in the diagnosis of clinically suspected Marjolin ulcer. AJR. American Journal of Roentgenology, 199(6), 1375–1379. doi:10.2214/AJR.11.8398

XIII. Onah, I. I., Okwor, B., & Onuigbo, W. I. B. (2010). Penetrating scalp Marjolin’s ulcer involving bone and dura mater in a Nigerian hospital: case report and literature review. Burns: Journal of the International Society for Burn Injuries, 36(4), e39-43. doi:10.1016/j.burns.2009.04.010

XIV. Oruç, M., Kankaya, Y., Sungur, N., Özer, K., Işık, V. M., Ulusoy, M. G., … Koçer, U. (2017). Clinicopathological evaluation of Marjolin ulcers over two decades. The Kaohsiung Journal of Medical Sciences, 33(7), 327–333. doi:10.1016/j.kjms.2017.04.008

XV. Xiang, F., Song, H.-P., & Huang, Y.-S. (2019). Clinical features and treatment of 140 cases of Marjolin’s ulcer at a major burn center in southwest China. Experimental and Therapeutic Medicine, 17(5), 3403–3410. doi:10.3892/etm.2019.7364

XVI. Alhysoni, K. A., Bukhari, S. M., & Hajjaj, M. F. (2016). Acute Marjolin’s ulcer in a postauricular scar after mastoidectomy. Case Reports in Otolaryngology, 2016, 2046954. doi:10.1155/2016/2046954

XVII. Chalya, P. L., Mabula, J. B., Rambau, P., Mchembe, M. D., Kahima, K. J., Chandika, A. B., … Gilyoma, J. M. (2012). Marjolin’s ulcers at a university teaching hospital in Northwestern Tanzania: a retrospective review of 56 cases. World Journal of Surgical Oncology, 10(1), 38. doi:10.1186/1477-7819-10-38

XVIII. Kanth, A. M., Heiman, A. J., Nair, L., Giammarino, A., Carpenter, C., Ricci, J. A., & Patel, A. (2021). Current trends in management of marjolin’s ulcer: A systematic review. Journal of Burn Care & Research: Official Publication of the American Burn Association, 42(2), 144–151. doi:10.1093/jbcr/iraa128

XIX. Ko, Y., Han, Y. M., Hwang, H. S., Kang, I. W., Hwang, D. H., Lee, E. S., & Lee, G. K. (2012). Role of 18F-FDG PET/CT in the diagnosis of clinically suspected Marjolin ulcer. AJR. American Journal of Roentgenology, 199(6), 1375–1379. doi:10.2214/AJR.11.8398

XX. Xiang, F., Song, H.-P., & Huang, Y.-S. (2019). Clinical features and treatment of 140 cases of Marjolin’s ulcer at a major burn center in southwest China. Experimental and Therapeutic Medicine, 17(5), 3403–3410. doi:10.3892/etm.2019.7364

XXI. Dörr, S., Lucke-Paulig, L., Vollmer, C., & Lobmann, R. (2019). Malignant transformation in diabetic foot ulcers-case reports and review of the literature. Geriatrics (Basel, Switzerland), 4(4), 62. doi:10.3390/geriatrics4040062

XXII. Bozkurt, M., Kapi, E., Kuvat, S. V., & Ozekinci, S. (2010). Current concepts in the management of Marjolin’s ulcers: outcomes from a standardized treatment protocol in 16 cases. Journal of Burn Care & Research: Official Publication of the American Burn Association, 31(5), 776–780. doi:10.1097/BCR.0b013e3181eed210

XXIII. Guo, B.-W., Pan, T., Chen, H.-B., Zhu, L., Tian, M., Wang, J.-C., & Li, X.-D. (2018). Clinicopathologic characteristics and prognosis analysis of marjolin’s ulcer in 40 cases. Current Medical Science, 38(6), 1038–1044. doi:10.1007/s11596-018-1981-3

XXIV. Kasai, T., Isayama, T., & Sekido, M. (2021). Squamous cell carcinoma arising from an ischial pressure ulcer initially suspected to be necrotizing soft tissue infection: A case report. Journal of Tissue Viability, 30(4), 621–625. doi:10.1016/j.jtv.2021.01.002

XXV. Khan, K., Giannone, A. L., Mehrabi, E., Khan, A., & Giannone, R. E. (2016). Marjolin’s ulcer complicating a pressure sore: The clock is ticking. The American Journal of Case Reports, 17, 111–114. doi:10.12659/ajcr.896352

XXVI. Pavlovic S, Wiley E, Guzman G, Morris D, Braniecki M. Marjolin ulcer: an overlooked entity. Int Wound J. 2011 Aug;8(4):419-24. doi: 10.1111/j.1742-481X.2011.00811.x. Epub 2011 May 17. PMID: 21585661; PMCID: PMC7950963.

Most read articles by the same author(s)