Liposarcoma: Clinical Presentation and Surgical Approach. Case Report

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José Manuel Marín Sánchez
Flavio Antonio De Sá Ribeiro
Luis Fernández De Cordoba
Ramiro Barajas Chávez
Javier Velázquez Herrera
Joksan Vargas López
Damián Hernández Bonilla
Salvador García Segura

Abstract

Liposarcoma is a rare malignant soft tissue neoplasm characterized by a nonspecific clinical presentation and variable biological behavior, which may lead to diagnostic delays, particularly in uncommon anatomical locations. We report the case of a 55-year-old female patient presenting with a progressively enlarging mass in the gluteal region, with a prolonged course and minimal initial symptoms. Imaging studies suggested a soft tissue neoplasm, and the diagnosis of liposarcoma was confirmed by histopathological examination. The patient underwent wide oncologic surgical resection with negative margins, which constituted the definitive treatment. The procedure was performed without intraoperative complications, with a favorable postoperative course and adequate functional preservation. This case report highlights the importance of including liposarcoma in the differential diagnosis of progressively growing gluteal masses, as well as the fundamental role of adequate surgical resection as the cornerstone of treatment, emphasizing the need for a timely and multidisciplinary approach to optimize oncologic and functional outcomes.

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How to Cite
Marín Sánchez, J. M. ., De Sá Ribeiro, F. A. ., De Cordoba, L. F., Barajas Chávez, R., Velázquez Herrera, J. ., Vargas López , J. ., Hernández Bonilla, D. ., & García Segura, S. . (2026). Liposarcoma: Clinical Presentation and Surgical Approach. Case Report. International Journal of Medical Science and Clinical Research Studies, 6(03), 477–483. https://doi.org/10.47191/ijmscrs/v6-i3-06
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References

I. Crago, A. M., & Singer, S. (2011). Clinical and molecular approaches to well-differentiated and dedifferentiated liposarcoma. Current Opinion in Oncology, 23(4), 373–378.

https://doi.org/10.1097/CCO.0b013e3283479f9a

II. Dalal, K. M., Antonescu, C. R., & Singer, S. (2008). Diagnosis and management of lipomatous tumors. Journal of Surgical Oncology, 97(4), 298–313. https://doi.org/10.1002/jso.20975

III. Dei Tos, A. P. (2014). Liposarcoma: New entities and evolving concepts. Annals of Diagnostic Pathology, 18(4), 252–266. https://doi.org/10.1016/j.anndiagpath.2014.03.002

IV. Fletcher, C. D. M., Bridge, J. A., Hogendoorn, P. C. W., & Mertens, F. (2013). WHO classification of tumours of soft tissue and bone (4th ed.). IARC Press.

V. Gronchi, A., Pollock, R. E., & Colombo, C. (2018). Quality of surgery and outcome in retroperitoneal soft tissue sarcoma. Annals of Surgery, 268(6), 959–966. https://doi.org/10.1097/SLA.0000000000002987

VI. Italiano, A., Toulmonde, M., & Cioffi, A. (2012). Advanced well-differentiated/dedifferentiated liposarcomas: Role of chemotherapy and radiotherapy. Critical Reviews in Oncology/Hematology, 84(1), 36–42.

https://doi.org/10.1016/j.critrevonc.2012.02.005

VII. Knebel, C., Lenze, U., Pohlig, F., Lenze, F., Harrasser, N., & von Eisenhart-Rothe, R. (2017). Prognostic factors and survival in liposarcoma patients. European Journal of Surgical Oncology, 43(2), 349–355. https://doi.org/10.1016/j.ejso.2016.09.011

VIII. Lewis, J. J., Antonescu, C. R., Leung, D. H. Y., Blumberg, D., Healey, J. H., & Brennan, M. F. (2000). Synoptic analysis of 155 patients with primary retroperitoneal liposarcoma. Annals of Surgery, 231(4), 526–534.

IX. https://doi.org/10.1097/00000658-200004000-00014

X. Mankin, H. J., Hornicek, F. J., & Rosenberg, A. E. (2005). Diagnosis, classification, and management of soft tissue sarcomas. Cancer Control, 12(1), 5–21. https://doi.org/10.1177/107327480501200102

XI. NCCN Clinical Practice Guidelines in Oncology. (2023). Soft tissue sarcoma (Version 2.2023). National Comprehensive Cancer Network. https://www.nccn.org

XII. Pisters, P. W. T., Leung, D. H., Woodruff, J., Shi, W., & Brennan, M. F. (1996). Analysis of prognostic factors in 1,041 patients with localized soft tissue sarcomas of the extremities. Journal of Clinical Oncology, 14(5), 1679–1689.

https://doi.org/10.1200/JCO.1996.14.5.1679

XIII. Sbaraglia, M., Bellan, E., & Dei Tos, A. P. (2021). The 2020 WHO classification of soft tissue tumours: News and perspectives. Pathologica, 113(2), 70–84. https://doi.org/10.32074/1591-951X-213

XIV. Strauss, D. C., Hayes, A. J., Thomas, J. M. (2010). Retroperitoneal tumours: Review of management. Annals of the Royal College of Surgeons of England, 92(7), 560–566.

https://doi.org/10.1308/003588410X12699663904599

XV. Trans-Atlantic Retroperitoneal Sarcoma Working Group. (2015). Management of primary retroperitoneal sarcoma: A consensus approach. Annals of Surgery, 261(6), 959–966. https://doi.org/10.1097/SLA.0000000000000869

XVI. Zagars, G. K., Ballo, M. T., Pisters, P. W. T., Pollock, R. E., Patel, S. R., Benjamin, R. S., & Evans, H. L. (2003). Prognostic factors for patients with localized soft-tissue sarcoma treated with conservation surgery and radiation therapy. Journal of Clinical Oncology, 21(2), 349–359. https://doi.org/10.1200/JCO.2003.05.109

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