Topical Meconium Improves Barrier Repair and Reduces Skin Inflammation in a Rat Model of Eczema

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Published: Dec 15, 2025
DOI: https://doi.org/10.47191/ijmscrs/v5-i12-11
Keywords:
atopic dermatitis, eczema, epidermal thickness, skin barrier function, topical therapy, wistar rat model

Main Article Content

Anudari Ichinkhorloo
Department of Cardiology, Institute of Medical Sciences, Ulaanbaatar 16081, Mongolia
Khuslen Batzorig
Department of Applied Neuroscience, Institute of Neuroscinece and Psychology, Mongolian Academy of Sciences, Ulaanbaatar 16066, Mongolia
Ganchimeg Dondov
Department of Oncology, Institute of Medical Sciences, Ulaanbaatar 16081, Mongolia
Batbold Batsaikhan
Department of Internal Medicine, Institute of Medical Sciences, Ulaanbaatar 16081, Mongolia
Tsend-Ayush Damba
School of Traditional Medicine, Mongolian National University of Medical Sciences
Bolortsetseg Jamyansuren
School of Traditional Medicine, Mongolian National University of Medical Sciences
Sodnomtsogt Lkhagvasuren
Department of Applied Neuroscience, Institute of Neuroscinece and Psychology, Mongolian Academy of Sciences, Ulaanbaatar 16066, Mongolia

Abstract

Eczema, or atopic dermatitis, is a chronic inflammatory skin condition characterized by epidermal barrier dysfunction and immune dysregulation. While traditionally considered a waste product, meconium—the first stool of neonates—contains various bioactive compounds that may influence immune responses and epithelial integrity.​ This study investigates the dermatological effects of meconium in a chemically induced eczema model in Wistar rats, focusing on its potential to modulate inflammation and promote skin barrier repair.​ Meconium samples were collected from healthy neonates and applied topically to rats with Veet-induced eczema. The experimental groups included untreated eczema controls, meconium-treated rats, Meebo ointment-treated rats (positive control), and a healthy control group. Clinical assessments of erythema, ulceration, and edema were conducted, alongside histopathological evaluations of epidermal thickness and immune cell infiltration. Statistical analyses were performed using ANOVA with post-hoc Tukey tests.​ Meconium treatment significantly reduced erythema and ulceration scores compared to untreated eczema controls (p<0.01) and increased epidermal thickness (p<0.05). While less effective than Meebo ointment, meconium demonstrated notable anti-inflammatory and regenerative properties.​ The findings suggest that meconium contains bioactive components capable of modulating skin inflammation and enhancing barrier repair, warranting further investigation into its potential therapeutic applications in dermatological conditions.

Article Details

How to Cite
Ichinkhorloo, A., Batzorig, K. ., Dondov, G. ., Batsaikhan, B. ., Damba, T.-A., Jamyansuren, B., & Lkhagvasuren, S. (2025). Topical Meconium Improves Barrier Repair and Reduces Skin Inflammation in a Rat Model of Eczema. International Journal of Medical Science and Clinical Research Studies, 5(12), 2009–2014. https://doi.org/10.47191/ijmscrs/v5-i12-11
Issue
Vol. 5 No. 12 (2025): Volume 05 Issue 12 December 2025
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Articles
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This work is licensed under a Creative Commons Attribution 4.0 International License.

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