Neurofibromatosis type 1 and High-risk Pregnancy: A Case Report

Abstract

Introduction: A high-risk pregnancy is the result of a disease present before pregnancy. Neurofibromatosis type 1 is a rare disease during pregnancy, autosomal dominant, with a mutation in the NF1 gene, on chromosome 17q11.2.

Clinical case: 38-year-old woman, Gestational age 1. Mother with neurofibromatosis type 1. The patient is hypertensive, diagnosed 7 years ago and currently treated with alpha-methyldopa 250 mg every 12 hours orally. She reports the diagnosis of neurofibromatosis type 1 since childhood. Without adequate prenatal control, with alterations in the Doppler ultrasound and complication of intrauterine growth restriction stage 1. A referral is made to third level of care and evaluation by maternal-fetal medicine

Discussion: Pregnancies in patients with neurofibromatosis are predisposed to obstetric complications due to the multisystemic nature of the disease. These patients have a higher incidence of spontaneous abortions, stillbirth, preeclampsia, intrauterine growth restriction (IUGR), oligohydramnios, premature birth and cerebrovascular complications.