Insights into Laron Syndrome: Unraveling the Molecular Basis, Clinical Manifestations, and Therapeutic Prospects
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Abstract
Laron Syndrome, a rare and intriguing genetic disorder, stands as a testament to the intricate interplay between genetics and endocrinology. This article delves into the comprehensive exploration of Laron Syndrome, elucidating its molecular underpinnings, intricate clinical presentations, and the evolving landscape of therapeutic interventions. By synthesizing current research and clinical observations, we aim to enhance the understanding of this syndrome, shedding light on the challenges posed by its unique pathophysiology. The exploration of growth hormone receptor insensitivity, molecular signaling cascades, and associated comorbidities will be discussed in detail, providing a foundation for future advancements in both diagnostic approaches and therapeutic strategies.
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References
I. Argente J. Clinical and molecular advances in the diagnosis of short stature.Molecular advances in the diagnosis of short stature. 2020;11(Suppl 1):15-25.
II. Bastidas A, Vásquez D, Cuestas P, Gómez E, Ramirez E. Roles of the hormone of the Growth in the infant and adult present. Sci Educ Med J. 2021;2(1):101-12.
III. Medeiros YG, Filho IF, Barata Bdos, Dia KC, De Lima ME, Leitão LM, et al. Revisão of Literature on the Implications of Diet on Growth Hormone Secretion (GH)/ literature review on the implications of Diet on Growth Hormone (GH) secretion. Brazilian Journal of Health Review. 2022;5(1):972-9.
IV. Cruvinel GN, Freitas AG, Fernandes NA, Melo DF, Fontana Nda, Filho AC, et al.Relação entre tratamento e estatura de meninas com puberdade Precoce Central Idiopática: Uma Revisão bibliográfica / correlation between treatment and height of girls with idiopathic central precocious puberty: A literature review. Brazilian Journal of Health Review. 2022;5(1):3606-14.
V. Argente J, Pérez-Jurado LA. Genetic causes of proportionate short stature. Best Pract Res Clin Endocrinol Metab. 2018;32(4):499-522.
VI. Yu H, Long W, Zhang X, Xu K, Guo J, Zhao H, Li H, Qing Y, Pan W, Jia B, Zhao HY,Huang X, Wei HJ. Generation of GHR-modified pigs as Laron syndrome models via a dualsgRNAs/Cas9 system and somatic cell nuclear transfer. J Transl Med. 2018 27;16(1):41
VII. Villela TR, Freire BL, Braga NTP, Arantes RR, Funari MFA, Jorge AAL, et al. Growth. hormone insensitivity (Laron syndrome): Report of a new family and review of Brazilian patients. Genet Mol Biol. 2019;42(4):1-6.
VIII. Bang P, Woelfle J, Perrot V, Sert C, Polak M. Effectiveness and safety of rhIGF1.therapy in patients with or without Laron syndrome. Eur J Endocrinol. 2021;184(2):267-76.
IX. Haim Werner, Lena Lapkina-Gendler, Laris Achlaug, Karthik Nagaraj, Lina Somri, Danielle Yaron- Saminsky, Metsada Pasmanik-Chor, rive Sarfstein, Zvi Laron SY. GenomeWide Profiling of Laron Syndrome Patients Identifies Novel Cancer Protection Pathways.Cells. 2019;8:1-15.
X. Guevara-Aguirre J, Bautista C, Torres C, Peña G, Guevara C, Palacios C, et al. Insights. from the clinical phenotype of subjects with Laron syndrome in Ecuador. Rev Endocr Metab Disord. 2021;22(1):59-70.
XI. Laron Z, Werner H. Laron syndrome - A historical perspective. Rev Endocr Metab Disord. 2021;22(1):31-41.
XII. Boro H, Rahman SH, Khatiwada S, Alam S, Khadgawat R. Laron syndrome: An experience of treatment of two cases. J Clin Transl Endocrinol Case Reports [Internet]. 2021;19:100076. Available from: https://doi.org/10.1016/j.jecr.2020.100076